Yazar "Coskun, Zeynep Mine" için listeleme
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Analysis of genetic polymorphisms associated with intervertebral disc degeneration
Kitis, Serkan; Coskun, Zeynep Mine; Tasdemir, Pelin; Tuncez, Ebru; Zamani, Ayse Gul; Acar, Aynur (C M B ASSOC, 2018)Intervertebral disc degeneration (IVDD) is a common degenerative spinal condition. Recent studies have shown that the incidence of disc herniation and disc degeneration may be explained by genetic factors. In this study, ... -
Biochemical and immunohistochemical changes in delta-9-tetrahydrocannabinol-treated type 2 diabetic rats
Coskun, Zeynep Mine; Bolkent, Sema (ELSEVIER GMBH, URBAN & FISCHER VERLAG, 2014)The regulation of glucose, lipid metabolism and immunoreactivities of insulin and glucagon peptides by delta-9-tetrahydrocannabinol (Delta(9)-THC) in diabetes were examined in an experimental rat model. Male Sprague-Dawley ... -
CB-1R and GLP-1R gene expressions and oxidative stress in the liver of diabetic rats treated with sitagliptin
Coskun, Zeynep Mine; Koyuturk, Meral; Karabulut, Sezin; Bolkent, Sema (POLISH ACAD SCIENCES INST PHARMACOLOGY, 2017)Background: Type 2 diabetes is a major health problem affecting millions of people.Controlled eating and regular physical activity are important for the management of type 2 diabetes. Dipeptidyl peptidase-4 enzyme (DPP-4) ... -
Dipeptidyl peptidase-4 inhibition prevents cell death via extrinsic and intrinsic apoptotic pathways in rat pancreas with insulin resistance
Nephan, Gulay; Coskun, Zeynep Mine; Bolkent, Sema (WILEY, 2018)The study aims to evaluate the effect of saxagliptin, a specific inhibitor of dipeptidyl peptidase-4 enzymes, on body weight gain, lipid profiles, and cell death through apoptosis in rats with insulin resistance (IR). Male ... -
Effects of boric-acid-applied green tea on the expressions of heat shock proteins in MCF-7 cells
Ersoz, Melike; Kacar, Ayse Karatug; Sezekler, Isil; Coskun, Zeynep Mine (CUKUROVA UNIV, FAC MEDICINE, 2019)Purpose: The study aims to examine the effects of boric acid at different concentrations applied to green tea on heat shock protein (HSP) 70 and HSP 90 in MCF-7 cells. Materials and Methods: Boric acid in sodium tetraborate ... -
ER Stress Amelioration by Saxagliptin Protects the Liver Against Fructose-induced Insulin Resistance
Coskun, Zeynep Mine (Elsevier Science Inc, 2020)Background/Aim. the study is aimed to demonstrate whether saxagliptin treatment may reduce endoplasmic reticulum (ER) stress, oxidative damage, and inflammation in the liver of fructose-induced insulin resistance (IR) rats. ... -
Evaluation of Delta(9)-tetrahydrocannabinol metabolites and oxidative stress in type 2 diabetic rats
Coskun, Zeynep Mine; Bolkent, Sema (MASHHAD UNIV MED SCIENCES, 2016)Objective(s): The object of the study is to examine the effects of Delta(9)-tetrahydrocannabinol (THC) against oxidative stress in the blood and excretion of THC metabolites in urine of type 2 diabetic rats. Materials and ... -
Immunohistochemical, apoptotic and biochemical changes by dipeptidyl peptidase-4 inhibitor-sitagliptin in type-2 diabetic rats
Karabulut, Sezin; Coskun, Zeynep Mine; Bolkent, Sema (POLISH ACAD SCIENCES INST PHARMACOLOGY, 2015)Background: Diabetes is a major public health problem that is rapidly increasing in prevalence. In this study, the effects of sitagliptin, a dipeptidyl peptidase-4 inhibitor, were examined on newborn diabetic rat model. ... -
Investigation of the biochemical and apoptotic changes in breast cancer cells treated with leaf extract from tea (Camellia sinensis L.) grown with added boric acid
Sezekler, Isil; Ersoz, Melike; Turan, Murat Ali; Coskun, Zeynep Mine (Univ Karachi, 2020)Tea obtained from the leaves of Camellia sinensis L., a medicinal plant, is a widely popular beverage. Deficiency in boron, a micronutrient for C. sinensis, affects the growth as well as the quality of tea. the aim of this ... -
Oxidative stress and inflammatory response of ghrelin on myocardial and aortic tissues in insulin-resistant rats
Coskun, Zeynep Mine; Beydogan, Alisa Bahar; Yanar, Karolin; Atukeren, Pinar; Bolkent, Sema (Wiley, 2021)Objectives This study was designed to clarify the effects of ghrelin on myocardial and aortic tissues in insulin-resistant rats. Methods Sprague-Dawley rats were divided into the following groups: control (Group 1), insulin ... -
The protective effects of Delta(9)-tetrahydrocannabinol against inflammation and oxidative stress in rat liver with fructose-induced hyperinsulinemia
Beydogan, Alisa Bahar; Coskun, Zeynep Mine; Bolkent, Sema (WILEY, 2019)Objectives A large amount of fructose is metabolized in the liver and causes hepatic functional damage. Delta(9)-tetrahydrocannabinol (THC) is known as a therapeutic agent for clinical and experimental applications. The ... -
Regulation of gene expression and biochemical changes in small intestine of newborn diabetic rats by exogenous ghrelin
Karatug, Ayse; Sacan, Ozlem; Coskun, Zeynep Mine; Bolkent, Sehnaz; Yanardag, Refiye; Turk, Neslihan; Bolkent, Sema (ELSEVIER SCIENCE INC, 2012)The aim of this study was to investigate (i) the cholecystokinin, somatostatin and apelin mRNA levels, (ii) the changes in levels and localization of these peptides, (iii) relation between these peptides, (iv) anti-apoptotic ...